The Molecules SS-31 and NMN Synergistically Improve Aged Heart Function
Scientists treated old mice with the molecules SS-31 and NMN (nicotinamide mononucleotide) separately to improve different heart functions and when...
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A Therapeutic Approach to Falling NAD+ Levels After Brain Injury
Scientists elaborate how NAD+ depletion compromises the ability of mitochondria to counteract free radical and reactive oxygen species buildup. Fol...
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Scientists From China Improve Bone Formation Deficiencies in Glucocorticoid-Induced Osteoporosis
Scientists at Nanchang University discovered NMN may be a therapeutic option for glucocorticoid-induced osteoporosis. Of the major side effects fro...
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NAD+ Keeps the Mouse Body Clock Young to Counter Aging
Boosting nicotinamide adenine dinucleotide (NAD+) levels restores improves circadian rhythms in old mice through youthful gene activation and metab...
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NMN Increases Oocyte Quality, Number, and Fertilization Ability
Nicotinamide mononucleotide (NMN) supplementation improves oocyte quality from naturally aged mice by restoring nicotinamide adenine dinucleotide (...
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NMN Administration Promotes Mitochondrial Health and Prevents Heart Failure
Scientists found NMN administration preserved mitochondrial health and prevented heart failure in mice deficient in a molecule that makes them susc...
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NMN Supplementation Promotes Brain Blood Vessel Rejuvenation
Scientists provide genetic evidence indicating NMN supplementation promotes rejuvenation of blood vessels providing nutrients to the brain. This Ap...
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Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice
Regulation of cerebral blood flow (CBF) to neuronal activity through neurovascular coupling (NVC) plays a critical role in maintaining healthy cogn...
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Ageing, neurodegeneration and brain rejuvenation
Although systemic diseases take the biggest toll on human health and well-being, increasingly, a failing brain is the arbiter of a death precede...
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NMN promotes osteogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrowV
Mesenchymal stromal cells (MSCs) can differentiate to various cell types including osteoblasts, chondrocytes, and adipocytes. This cellular flex...
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NMN attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway
Replenishment of NAD+ has been shown to protect against brain disorders such as amyotrophic lateral sclerosis and ischemic stroke. However, whet...
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Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults
Nicotinamide adenine dinucleotide (NAD+) has emerged as a critical co-substrate for enzymes involved in the beneficial effects of regular calori...
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