Research

Study Indicates NMN Has Anti-Aging Potential for Kidneys

NMN’s restoration of youthful kidney protein levels in aged mice may translate therapeutically to humans. The world’s population of older adults co...

Preliminary Clinical Trial Data Shows Elevated NAD+ Improves Inflammatory Response in Heart Failure in Human Patients

NR supplementation improves mitochondrial function and affects inflammatory response in heart failure patients Although inflammation is a way that ...

Lilly Acquires Disarm Therapeutics and NAD+ Metabolism Drug to Combat Neurological Diseases

The addition of Disarm's promising programs for axonal degeneration expands Eli Lilly and Company’s R&D efforts in pain and neurodegeneration. ...

Elevated NAD+ May Protect Against Heart Failure in Human Patients

NR supplementation provides a novel heart failure therapy by preserving cardiac function and blocking inflammation. Although inflammation is a way ...

NMN Improves Depression Symptoms in Mice

Scientists find NMN improves depression-like behavior, displayed as immobility in swim tests, and cellular energy production in mice. About 16.2 mi...

Nicotinamide Protects Skin Cells From UV-Induced DNA Damage

Skin cells treated with a form of vitamin B3 activates DNA repair programs. While many people love getting some sun, they know how damaging catchin...

Immune Cells Expressing CD38 Drive NAD+ Decline with Age

A new study indicates age-related inflammation can stimulate CD38 positive immune cell consumption of NAD+. An essential molecule for cellular ener...

Neuroscientists Revive Memory Deficits and Brain Cell Loss in Diabetic Rats

Nicotinamide mononucleotide (NMN) intervention protects neurons and memory from diabetes-induced brain degeneration in rats. The brains of many peo...

Aging Might Be Reversible — Fixing the Miscommunications in Cells with NAD+

Miscommunication between mitochondria and the nucleus accelerates aging, but NAD+ supplementation helps restore the conversation and reverses signs...

NAD+ Metabolism Promotes Sensitivity to Anti-Cancer Therapy

NAD+ metabolism drives tumor escape from the immune response, but boosting NAD+ levels improves the efficacy of anti-cancer therapy. Nicotinamide ...

Replenishing NAD+ Reduces Defects in Patient Cells with Frayed Chromosome Ends

NR supplementation alleviates defects in cells from dyskeratosis congenita patients. Stretches of repetitive DNA called telomeres stop the ends of ...

The Nampt/NAD+ Axis may be a Potent Therapeutic Target for Atrial Fibrillation

NAD+ precursor decreases atrial fibrillation susceptibility and duration in mice. Aging and obesity are prominent risk factors for the onset of atr...

NAD+ Binds to and Inhibits a Protein that Promotes Degeneration of Neurons

Investigators propose that a newly revealed nicotinamide adenine dinucleotide (NAD+) binding site of Sarm1 may be a promising drug target. Degenera...