Research

Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice

Regulation of cerebral blood flow (CBF) to neuronal activity through neurovascular coupling (NVC) plays a critical role in maintaining healthy cogn...

Ageing, neurodegeneration and brain rejuvenation

Although systemic diseases take the biggest toll on human health and well-being, increasingly, a failing brain is the arbiter of a death precede...

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NMN promotes osteogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrowV

Mesenchymal stromal cells (MSCs) can differentiate to various cell types including osteoblasts, chondrocytes, and adipocytes. This cellular flex...

NMN attenuates brain injury after intracerebral hemorrhage by activating Nrf2/HO-1 signaling pathway

Replenishment of NAD+ has been shown to protect against brain disorders such as amyotrophic lateral sclerosis and ischemic stroke. However, whet...

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

Nicotinamide adenine dinucleotide (NAD+) has emerged as a critical co-substrate for enzymes involved in the beneficial effects of regular calori...

Longevity In A Bottle

“I think once the world realizes that it’s possible to delay aging and keep people healthy for longer, then the resources will become available to ...